{"id":9580,"date":"2021-04-02T02:51:54","date_gmt":"2021-04-02T06:51:54","guid":{"rendered":"https:\/\/cancerawarenessnews.com\/introduction-to-cancer-biology-part-1-abnormal-signal-transduction\/"},"modified":"2021-04-02T02:51:54","modified_gmt":"2021-04-02T06:51:54","slug":"introduction-to-cancer-biology-part-1-abnormal-signal-transduction","status":"publish","type":"post","link":"http:\/\/cancerawarenessnews.com\/introduction-to-cancer-biology-part-1-abnormal-signal-transduction\/","title":{"rendered":"Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction"},"content":{"rendered":"<p><div
class=\"jetpack-video-wrapper\"><iframe
loading=\"lazy\" title=\"Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction\" width=\"640\" height=\"480\" src=\"https:\/\/www.youtube.com\/embed\/jjfYQMW_nek?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/p>\n<p>This animation is the first part of the series &#8220;An Introduction to Cancer Biology&#8221;, and also clarifies the device of irregular signal transduction leading to uncontrolled cell proliferation. This computer animation likewise gives a summary of the potential targets of anticancer treatments.<\/p>\n<p>REFERENCES:<br
\/>\n1. Hanahan D, Weinberg RA. The characteristics of cancer cells. Cell. 2000 Jan 7; 100( 1 ):57 -70.<\/p>\n<p>Review of skin growth element receptor biology. Int J Radiat Oncol Biol Phys.<\/p>\n<p>3. Gerharz CD, Ramp U, Reinecke P, et al. Evaluation of growth factor-dependent signalling in human epithelioid sarcoma cell lines. Ideas to the function of autocrine, paracrine and also juxtacrine interactions in epithelioid sarcoma. Eur J Cancer. 2000 Jun; 36( 9 ):1171 -9.<\/p>\n<p>Potapova O, Fakhrai H, Mercola D. Growth factor PDGF-B\/v-sis confers a tumorigenic phenotype to human lump cells birthing PDGF receptors yet not to cells devoid of receptors: evidence for an autocrine, yet not a paracrine, mechanism. Int J Cancer.<\/p>\n<p>Skin growth aspect receptor moderates boosted cell spreading, movement, and aggregation in esophageal keratinocytes in vitro and also in vivo. J Biol Chem.<\/p>\n<p>6. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA. When overexpressed in NIH\/3T3 cells, erbb-2 is a powerful oncogene. Science. 1987 Jul 10; 237( 4811 ):178 -82.<\/p>\n<p>Skin development factor ligand-independent, unregulated, cell-transforming potential of a naturally happening human mutant EGFRvIII gene. Cell Growth Differ.<\/p>\n<p>Egeblad M, Mortensen OH, Jaattela M. Truncated ErbB2 receptor improves ErbB1 signaling as well as causes reversible, ERK-independent loss of epithelial morphology. Int J Cancer.<\/p>\n<p>9. Lage A, Crombet T, Gonz\u00e1lez G. Targeting epidermal growth factor receptor signaling: early results and future patterns in oncology. Ann Med. 2003; 35( 5 ):327 -36.<\/p>\n<p>10. Adjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer cells therapy. J Clin Oncol. 2005 Aug 10; 23( 23 ):5386 -403.<\/p>\n<p>Raf: a calculated target for restorative development versus cancer. J Clin Oncol.<\/p>\n<p>12. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000 Oct 13; 103( 2 ):253 -62.<\/p>\n<p>13. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001 Feb; 2( 2 ):127 -37.<\/p>\n<p>14. Igney FH, Krammer PH. Death as well as anti-death: tumor resistance to apoptosis. Nat Rev Cancer. 2002 Apr; 2( 4 ):277 -88.<\/p>\n<p>Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, Diederich M. An intro to the molecular devices of apoptosis.<\/p>\n<p>Chemoresistance: influence of nuclear variable (NF)-kappaB restraint by tiny conflicting RNA. Clin Cancer Res.<\/p>\n<p>17. Foo P. Metastasis: The trip of mobile cancer cells. Harvard Science Review. Spring 2002; 30-2.<\/p>\n<p>18. Hicklin DJ, Ellis LM. Function of the vascular endothelial growth variable path in tumor growth as well as angiogenesis. J Clin Oncol. 2005 Feb 10; 23( 5 ):1011 -27.<\/p>\n<p>19. Ellis LM. Epidermal development aspect receptor in lump angiogenesis. Hematol Oncol Clin North Am. 2004 Oct; 18( 5 ):1007 -21.<\/p>\n<p>Bevacizumab plus Irinotecan, Fluorouracil, and also Leucovorin for Metastatic Colorectal Cancer. N Engl J Med.<\/p>\n<p>Activity of SU11248, a multitargeted prevention of vascular endothelial development aspect receptor and also platelet-derived growth aspect receptor, in individuals with metastatic renal cell carcinoma. J Clin Oncol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This animation is the first part of the series &#8220;An Introduction to Cancer Biology&#8221;, and also clarifies the device of irregular signal transduction leading to uncontrolled cell proliferation. This computer animation likewise gives a summary of the potential targets of anticancer treatments. REFERENCES: 1. Hanahan D, Weinberg RA. The characteristics of cancer cells. Cell. 2000 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9583,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[19],"tags":[1660,3922,2911,2910,3926,2922,21,2916,2919,2915,2918,257,2917,2921,22,59,2908,2923,1862,85,11043,2907,2906,33,88,2924,2914,2925,190,11041,2913,2926,2927,296,11046,11045,11047,2912,11048,2909,11044,11042,11049,2920],"class_list":["post-9580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-breast-cancer","tag-alzheimers","tag-animation","tag-anti-bacteria","tag-anti-viral","tag-biology","tag-bladder-cancer","tag-breast-cancer","tag-breast-cancer-causes","tag-breast-cancer-causes-and-symptoms","tag-breast-cancer-definition","tag-breast-cancer-pictures","tag-breast-cancer-treatment","tag-breast-cancer-types","tag-breast-cancer-wiki","tag-cancer","tag-cancer-treatment","tag-cholesterol","tag-colorectal-cancer","tag-depression","tag-diabetes","tag-egfr","tag-esophageal-cancer","tag-healthy-cures","tag-heart-disease","tag-high-blood-pressure","tag-kidney-cancer","tag-lung-cancer-treatment","tag-lymphoma","tag-melanoma","tag-mtor","tag-naturopathic-cures","tag-non-hodgkin","tag-oropharyngeal-cancer","tag-parkinsons","tag-pi3k","tag-proliferation","tag-receptor","tag-skincare","tag-targeted-therapy","tag-tooth-decay","tag-tumorigenesis","tag-tyrosine-kinase","tag-vegf","tag-what-is-breast-cancer-symptoms"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/cancerawarenessnews.com\/wp-content\/uploads\/2021\/04\/sddefault-1.jpg?fit=640%2C480","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/posts\/9580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/comments?post=9580"}],"version-history":[{"count":0,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/posts\/9580\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/media\/9583"}],"wp:attachment":[{"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/media?parent=9580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/categories?post=9580"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/cancerawarenessnews.com\/wp-json\/wp\/v2\/tags?post=9580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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