Understanding & Conquering Depression | Huberman Lab Podcast #34

This episode, I clarify what significant depression goes to the organic and mental degree and the various treatments that peer-reviewed studies have actually revealed can assist deal with and protect against anxiety. I describe the 3 major chemical systems that are changed in anxiety: norepinephrine, serotonin and dopamine. I go over hereditary predispositions to depression and just how tension, thyroid hormone and cortisol play a duty in lots of types of clinical depression. I additionally review inflammation as a common feature of many anxiety signs. I examine 8 particular science-supported methods for treating and avoiding clinical depression, consisting of EPA fats (which have been revealed to rival particular prescription treatments), how workout shields versus depression, researches of creatine, adjusting dopamine balance and even more. I additionally review the outcomes of ongoing clinical trials for ketamine and psilocybin for depression, just how these substances work and finally, I examine how ketogenic diet regimens can aid in particular situations of clinical depression, specifically treatment-resistant major anxiety.

#Depression #HubermanLab #Dopamine

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Hyperlinks:
Testimonial of EPAs for the Treatment of Depression – https://bit.ly/2Wl15ti
Evaluation of Creatine for the Treatment of Depression – https://www.mdpi.com/520864
Recent Study on the Clinical Use of Psilocybin for Treatment of Depression – https://bit.ly/3sFSGMM

Timestamps:
00:00:00 Mood Disorders & Maintaining Mental Health (Protocol 1).
00:07:10 Sponsors.
00:11:15 Major Depression.
00:18:40 “Anti-Self” Confabulation.
00:21:42 Autonomic (Vegetative) Symptoms of Depression.
00:26:58 Dopamine, serotonin & norepinephrine.
00:31:50 SSRIs (Prozac, Zoloft, and so on): Selective Serotonin Reuptake Inhibitors.
00:37:00 Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions.
00:39:33 Physical & Emotional Pain are Linked: Substance P.
00:41:50 Hormones & Depression: Thyroid & Cortisol.
00:46:50 Genetic Susceptibility to Depression: Impact of Stress.
00:50:50 Understanding Biological Mechanism Is Key: Recipes versus Skills.
00:52:50 Tools for Dealing with Depression: Logic & Implementation (Protocol 2).
00:56:25 Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc 00:59:20 Protocol 3: Essential Fatty Acids (Omega-3, EPAs: Eicosapentaenoic Acid) *.
01:02:50 How EPAs Help Offset Depression: Serotonin Synthesis, Kynurenine, Quinolinic Acid.
01:05:25 Protocol 4: How Exercise Offsets Depression.
01:11:44 Protocol 5: Creatine Monohydrate, Forebrain Function & NMDA receptors *.
01:20:30 Protocol 6 *: Ketamine, PCP (* Prescription-Only), & NMDA-Receptor Function.
01:33:08 Protocol 7 *: Psychedelics (* In Clinical Trials) for Major Depression: Psilocybin *.
01:47:00 Protocol 8: Ketogenic Diet, GABA (Gamma-Aminobutyric Acid).
01:54:50 Summary of Protocols Covered.
02:00:10 Support & Additional Resources.

Please note that The Huberman Lab Podcast is distinctive from Dr. Huberman’s teaching and study roles at Stanford University School of Medicine. The details supplied in this program is not clinical guidance, nor should it be taken or applied as a replacement for clinical advice. The Huberman Lab Podcast, its employees, guests and associates assume no responsibility for the application of the information gone over.

Title Card Photo Credit: Mike Blabac – https://www.blabacphoto.com.